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Pain School
Pain School
an educational project of IASP an educational project of IASP an educational project of IASP


EPS 2018 • Pain: from Fetus to Old Age

Pain: from Fetus to Old Age

Siena, Italy • 10-17 June 2018

Siena, Italy • 10-17 June 2018


Preliminary Programme

Ln Faculty Lectures (L1-L19)
Wn Interactive Workshops, Seminars and Special Presentations (W1-W10)
Sn Scholars’ Oral Presentations (S1-S31)

  • Sunday, 10 June

    11:00-18:00 Arrival of Scholars and Faculty at the Certosa di Pontignano

    Assignment to rooms in the hotel wing of the Certosa. All food during the week will be provided by the restaurant of the Certosa (breakfast, lunch and dinner).

    15:30-16:30 A short guided tour through the Certosa, its Chapel, Cloisters and Garden
    17:30-19:00 Opening Ceremony

    L1 Welcome
    Anna Maria Aloisi, School Director, Siena Italy and Bill Maixner, Durham, NC, USA

    The European Pain School 2018
    Bill Maixner, Durham, NC, USA

    Greetings from the University of Siena

    Grünenthal Scientific Relations Management, Aachen, Germany

    Pain: a new scientific discipline
    Marshall Devor, Jerusalem, Israel

    About the IASP and how you can participate
    Lars Arendt-Nielsen, President-elect IASP, Aalborg, Denmark

    The Certosa di Pontignano and its history
    Giancarlo Carli, Siena, Italy

    Monasteries, medieval forerunners of Universities and Hospitals
    Manfred Zimmermann, Heidelberg, Germany

    Scholars’ self-introduction

    20:30 Wine reception followed by dinner, then leisure time


  • Monday, 11 June

    Opening remarks
    Bill Maixner, Durham, NC, USA
    9:00-10:00 L2 The pain system: fundamentals of pain processing in the PNS and CNS
    Jordi Serra (Barcelona, Spain)
    10:00-10:15 S1 Does spinal glia activation involve in chemotherapy induced neuropathic pain?
    Duygu Krings (Aachen, Germany)
    10:15-10:30 S2 Pain specific local anesthesia without neurotoxicity
    Yishai Kushnir (Jerusalem, Israel)
    10:30-11:00 Coffee break
    11:00-11:15 S3 Investigating the role of prokineticin system in a murine model of chemotherapy-induced peripheral neuropathy
    Giorgia Moschetti (Milan, Italy)
    11:15-11:30 S4 Effect of short-term noxious heat stimulation on human experimental models of itch
    Daniele Riccio (Aalborg, Denmark)
    11:30-12:30 L3 Neural plasticity: hyperexcitability in neurons and neuronal networks as a generator of chronic pain
    Marshall Devor (Jerusalem, Israel)
    13:00-15:00 Lunch break
    15:00-16:00 L4 The role of PNS drive in CNS sensitisation of chronic pain patients
    Lars Arendt-Nielsen (Aalborg, Denmark)
    16:00-16:15 S5 Age-related dysfunction in endogenous pain inhibition and its association with cognitive inhibition and changes in frontal brain areas
    Stefanie Bunk (Groningen, The Netherlands)
    16:15-16:30 S6 Project Plan: morphological and functional brain alterations in fibromyalgia patients
    Hans-Christoph Aster (Würzburg, Germany)
    16:30-17:00 Coffee break
    17:00-17:15 S7 Does anxiety enlarge reflex receptive fields?
    Edward Lannon (Tulsa, OK, USA)
    17:15-17:30 S8 Task-dependent cortical reorganization in sensorimotor body representations in amputees — impact on current theories of phantom pain
    Christopher Milde (Mannehim, Germany)
    17:30-18:30 L5 Pain in dementia
    Miriam Kunz (Groningen, The Netherlands)
    20:00-21:30 Dinner in the small Cloister
    21:30 W1 Behavioral tests & tools in pain research, a hands-on presentation of equipment for experimental pain research
    Federico Oggioni (Ugo Basile Srl. Gemonio, Varese, Italy)


  • Tuesday, 12 June

    9:00-10:00 L6 Unraveling the mysteries of complex persistent pain conditions
    Bill Maixner (Durham, NC, USA)
    10:00-10:15 S9 Analgesic and neuroprotective effect of bromelain in sciatic nerve ligated model of neuropathic pain in Wistar rats
    Ahmed Bakare (Ilorin, Nigeria)
    10:15-10:30 S10 Central neuropathic pain in multiple sclerosis is associated with widespread damage of pain processing and modulation pathways
    Michal Rivel (Tel Aviv, Israel)
    10:30-11:00 Coffee break
    11:00-11:15 S11 Peripheral and central nervous contributions to changes in heat pain perception during repetitive laser stimulation in healthy subjects
    Daniela Rosenberger (Mannheim, Germany)
    11:15-11:30 S12 Spatially distributed injections of NGF induces enlarged area of pain and prolonged muscle hypersensitivity
    Line Sørensen (Aalborg, Denmark)
    11:30-12:30 L7 Role of melatonin in pain modulation
    Giancarlo Carli (Siena, Italy)
    13:00-15:00 Lunch break
    15:00-16:00 L8 Can the facial expression of pain substitute the self-report of pain?
    Miriam Kunz (Groningen, The Netherlands)
    16:00-16:15 S13 Self-management interventions for women with cardiac pain: a systematic review and meta-analysis
    Ann Bjørnnes (Toronto, ON, Canada)
    16:15-16:30 S14 Resting-state fMRI functional connectivity within cortico-limbic networks is linked to the individual magnitude of emotional pain modulation
    Norma Rosenek (Reading, UK)
    16:30-17:00 Coffee break
    17:00-17:15 S15 The efficacy of postoperative pain management in total hip arthroplasty
    Jolanta Sułek (Krakow, Poland)
    17:15-17:30 S16 Investigating the impact of visual experience on the perception of nociceptive stimuli in normally sighted and visually deprived people
    Camille Vanderclausen (Brussels, Belgium)
    17:30-18:30 L9 The efficacy of psychological approaches in acute and chronic paediatric pain
    Christina Liossi (Southampton, UK)
    20:00-21:30 Dinner in the small Cloister
    21:30 W2 Organization of debate teams


  • Wednesday, 13 June

    9:00-10:00 L10 Measuring and modulating infant pain
    Rebeccah Slater (Oxford, UK)
    10:00-10:15 S17 What’s up Doc? Treating children in chronic pain. Why medicine should think less doctor, more storyteller
    Mary Lockwood (Manchester, UK)
    10:15-10:30 S18 Morphological and functional changes in the nociceptive system in rat models of diabetic peripheral neuropathy – contribution of TRP channels?
    Bastian Schlickenrieder (Mannheim, Germany)
    10:30-11:00 Coffee break
    11:00-11:15 S19 Intensive interdisciplinary pain treatment for pediatric chronic headache: examining improvements in physical function and participation
    Julie Shulman (Boston, MA, USA)
    11:15-11:30 S20 Scorpion α-toxins affect intracellular signaling in primary sensory neurons via TTX-sensitive voltage gated sodium channels
    Marianne Van Cann (Cologne, Germany)
    11:30-12:30 L11 Assessing the pain code by intraneural recording in humans
    Jordi Serra (Barcelona, Spain)
    13:00-15:00 Lunch break
    15:00-16:00 L12 Methodologies in clinical assessment of pain phenotypes: biopsychosocial factors
    Bill Maixner (Durham, NC, USA)
    16:00-16:15 S21 Why do analgesic clinical trials fail?
    Raheleh Heidari (Feidt) (Basel, Switzerland)
    16:15-16:30 S22 EEG signature of systemilycsystemic induced anesthesia vs induction via the mesopontine tegmental anesthesia area (MPTA)
    Tamir Avigdor (Jerusalem, Israel)
    16:30-16:45 S23 Pain-free surgery: anesthesia-like state induction and maintenance by focal activation of extra-synaptic GABAA receptors, but not glycine receptors
    Mark Baron (Jerusalem, Israel)
    16:45-17:15 Coffee break
    17:15-18:15 L13 Pain and consciousness
    Marshall Devor (Jerusalem, Israel)
    20:00-21:30 Dinner in the small Cloister
    21:30 W3 EPS 2018 Neuropathic Pain Quiz!!
    Jordi Serra (Moderator)
    Stargazing night...
    with Prof. Vincenzo Millucci


  • Thursday, 14 June

    9:00-10:00 L14 The postnatal development of spinal sensory circuits
    Stephanie Koch (London, UK)
    10:00-10:30 W4 Duetto on pain-sensation and suffering
    Marshall Devor (Moderator)
    a) Topic: “When is pain tolerance shaped more, in infancy or the school years”
    Faculty: Christina Liossi and Rebeccah Slater
    10:30-11:00 Coffee break
    11:00-11:30 W4 Duetto on pain-sensation and suffering
    Marshall Devor (Moderator)
    b) Topic: "How can we tell if pain originates in the PNS or CNS?”
    Faculty: Jordi Serra and Stephanie Koch
    11:30-12:30 L15 The development of pain perception in early life
    Rebeccah Slater (Oxford, UK)
    13:00-15:00 Lunch break
    Afternoon and Evening: Excursion to Siena old town
    15:00-18:00 Guided tour to historical Siena, visit of the Cathedral and City Hall and to a 'Contrada' Museum
    19:00-20:00 Aperitif in Piazza del Campo
    20:00-24:00 Free time for Scholars in Siena / Faculty Dinner
    (plan to return to the Certosa on your own)


  • Friday, 15 June

    9:00-10:00 L16 Neuroinflammation and pain
    Jürgen Sandkühler (Vienna, Austria)
    10:00-10:15 S24 Axonal GABAA modulates C-fibres excitability and mediates neuron-glia cross talk via allopregnanolone
    Veronica Bonalume (Milan, Italy)
    10:15-10:30 S25 Beyond evoked endpoints? Sleep, cognition and motivation in rat models of chronic inflammatory pain
    Gary Gilmour (Windlesham, UK)
    10:30-11:00 Coffee break
    11:00-11:15 S26 Disinhibition of spinal cord pain pathways underlies neuropathic pain hypersensitivity in rodents of both sexes
    Josiane Mapplebeck (Toronto, ON, Canada)
    11:15-11:30 S27 Involvement of AT2R and HCN2 ion channels in inflammatory pain hypersensitivity in mice
    Larissa Garcia Pinto (London, UK)
    11:30-12:30 L17 The Marsili syndrom
    Anna Maria Aloisi (Siena, Italy)
    13:00-15:00 Lunch break
    15:00-16:00 L18 Spinal inhibition of touch
    Stephanie Koch (London, UK)
    16:00-16:15 S28 Effects of methylglyoxal, glyoxal and 3-DG on cutaneous nociceptors: mechanisms of sensitization, excitation or desensitization
    Anna Becker (Erlangen, Germany)
    16:15-16:30 S29 Divergent modulation of nociception by glutamatergic and GABAergic neuronal subpopulations in the periaqueductal gray
    Jose Grajales-Reyes (St. Louis, MO, USA)
    16:30-17:00 Coffee break
    17:00-17:15 S30 Trends in tramadol
    Kate Liu (Aachen, Germany)
    17:15-17:30 S31 Adherence to prophylaxis pharmacotherapies in patients with Medication Overuse Headache: a 10-year experience in a single-centre
    Lanfranco Pellesi (Modena, Italy)
    17:30-18:30 L19 Central pain amplifier
    Jürgen Sandkühler (Vienna, Austria)
    20:00-21:30 Dinner in the small Cloister
    21:30 W6 Experiments in the pain laboratory – sensory dissociation during limb ischemia
    Jordi Serra (Barcelona, Spain)


  • Saturday, 16 June

    9:00-10:00 W7 Ethical considerations and limitations of pain research and treatment in humans and animals
    Manfred Zimmermann (Heidelberg, Germany)
    20 min presentation followed by a panel discussion of specific ethical issues, with:
    Manfred Zimmerman, Jordi Serra, Marshall Devor and Faculty
    10:00-10:30 W8 Scholars’ controversial debates on the following topics
    Marshall Devor and Jordi Serra (Moderators)
    a) Resolved: “Intense focal pain is worse than diffuse widespread pain”
    10:30-11:00 Coffee break
    11:00-11:30 W8 Scholars’ controversial debates on the following topics
    Marshall Devor and Jordi Serra (Moderators)
    b) Resolved: “Late sensory changes following early trauma is adaptive for the child later in life”
    11:30-12:00 W9 Open Forum - Pain Science and Medicine: how have we been doing?
    Neural mechanisms
    Old drugs, new drugs
    Procedures and surgery
    Organizing concepts (not a symptom, bio-psychosocial, not just medical)
    Discussants: Marshall Devor, Jordi Serra, Jürgen Sandkühler, Christina Liossi, Bill Maixner
    12:00-12:30 W10 Evaluation of EPS 2018 by Scholars and Faculty, parting words
    - General discussion of the EPS experience and suggestions on how to modify/improve EPS in the future
    - Parting words from Anna Maria Aloisi and Bill Maixner

    13:00-15:00 Lunch break
    16:00 Departure to Terme Antica Querciolaia, Rapolano Terme Spa, Dinner and Live Music
    00:00 Return to the Certosa


  • Sunday, 17 June

      Departure from the Certosa di Pontignano